AI辅助个性化mRNA癌症疫苗III期试验成功
This is freaking huge: For the first time, a AI-assisted personalized mRNA cance…
This is freaking huge: For the first time, a AI-assisted personalized mRNA cancer treatment has succeeded in a Phase 3 trial.
这真是巨大突破：首次，一种AI辅助的个性化mRNA癌症治疗在III期试验中取得成功。
Moderna and Merck sequence each patient’s tumor and compare it with their healthy DNA. AI then helps identify which of the tumor’s mutations are most likely to trigger an immune response.
Moderna和Merck对每位患者的肿瘤进行测序，并与他们的健康DNA进行比较。AI随后帮助识别肿瘤中哪些突变最可能触发免疫反应。
From those targets, Moderna produces an individual mRNA treatment encoding up to 34 neoantigens, The earlier Phase 2 trial followed patients with surgically removed high-risk melanoma for five years:
基于这些靶点，Moderna生产出一种个体化的mRNA治疗，编码多达34种新抗原。早前的II期试验对手术切除高风险黑色素瘤的患者进行了五年随访：
- 68.8% remained cancer-free, compared with 49.1% on Keytruda alone - 49% lower risk of recurrence or death - 59% lower risk of distant metastasis or death
- 68.8%的患者保持无癌状态，而单独使用Keytruda的为49.1% - 复发或死亡风险降低49% - 远处转移或死亡风险降低59%
Now the much larger Phase 3 trial involving 1,137 patients has also succeeded.
现在，涉及1137名患者的更大规模III期试验也取得了成功。
Absolutely incredible. Dario was right: cancer will be cured in just a few years!
绝对令人难以置信。Dario说得对：癌症将在短短几年内被治愈！
更进一步：量化金融体系
看懂新闻只是起点——沿量化金融路径，把它变成能交付的工程能力